Familial aplasia cutis.

Abstract

There are 2 variants of aplasia cutis of the scalp: the membranous form characterized by small patches covered with thin skin similar to membrane and the non membranous form characterized by large ulcerated patches of irregular shape that heal with hypertrophic scar (3). However, there are intermediate forms such as small patches ulcerated at birth healing with scar. The large ulcerated patches, especially those ones with gangrenous appearance, may be associated with defects in the sagittal sinus and delay of closure of the skull (2). The large ulcerated lesions most often are hereditary and transmitted as an autosomal dominant trait, as in our case: in a review of the literature (1) of 26 families with inherited aplasia cutis 19 had largely ulcerated lesions at birth.