Tibial dysplasia in neurofibromatosis type 1.

Abstract

The subjects with NF1 present some characteristic bone abnormalities. Among the latter there is tibial dysplasia, which is usually located between the middle third and the distal third of the tibia. In this site there is thinning of the bone, due to narrowing of the medullary, whereas the cortical can be normal or thickened (3). The weakening of the bone is responsible for an anterolateral bending of the tibia -tibia procurvata et vara- (2). The latter can be complicated by pathological fractures and mainly by defective formation of bone callus and non rejoining of the two fragments (pseudoarthrosis).
Lovastatin may favor the repair processes of the bone.