Hypomelanosis of Ito: ultrastructural study.

Abstract

A 7-year-old girl with lto syndrome and complex neurologic disorders is repor­ted. The histologic and ultrastructural examination of a skin biopsy demonstra­ted, in hypopigmented areas, a reduction of number and size of melanosomes in basal keratinocytes. In addition, mild regressive changes of melanocytes were observed. No changes were demonstrated in Langerhans cells as well as nerve fi­bres. Namely, no relationships were observed between nerve endings and mela­nocytes.