Autoimmune bullous dermatoses.

Abstract

In these dermatoses the blister is due to an alteration of the structures allowing the adhesion between the single keratinocytes or between the basal cells of the epidermis and the underlying dermis. The alteration of the structures of adhesion occurs because such structures are the target of an autoimmune reaction of the immune system. This reaction in turn occurs in genetically predisposed subjects, following events, usually trivial, which modify the antigenic properties of the same structures.