Early-onset androgenetic alopecia: a clue to the diagnosis of tricho-rhino-phalangeal syndrome.

Abstract

The tricho-rhino-phalangeal syndrome type 1 is a rare genetic multisystem disease characterized by the triad as follows: sparse and slow-growing hair, pear-shaped nose and bones disorders. The syndrome is characterized by autosomal dominant inheritance with high penetrance and variable expressivity. Here is reported a patient showing the clinical features of the syndrome in order to alert the dermatologists to cases of early-onset androgenetic alopecia for possible diagnosis of genetic diseases.